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High and low frequency non-synonymous single nucleotide polymorphisms (SNPs) in human CEACAM1 N domain. ( A ) The amino acid sequences of the mature CEACAM1 N domain (leader sequences removed) from human (Hsa), bonobo (Ppa), and chimpanzee (Ptr) were aligned using the <t>KALIGN</t> multiple <t>protein</t> <t>sequence</t> alignment program. Amino acids deviating from the human sequence are underlined. The position of common SNPs found in certain African tribes are indicated by green boxes. A less common SNP at a position with variation in the other apes is marked in blue. A low frequency, functionally relevant SNP is boxed with red lines. The degree of conservation of the sequences is shown at the bottom of the graph [* = identical (red), : = conservative changes (green), . = less stringent conservative changes (blue)]. The location, sequence, and name of active human CEACAM1 peptides functionally tested in a granulocyte activation assay [ , , ] are highlighted and shown below the CEACAM1 N exon amino acid sequence alignment. ( B ) High and selected low frequency non-synonymous SNPs were derived from the 1000 Genomes Project Phase 3 and Gambian Genome Variation Project; their highest population frequency in the indicated population and corresponding identifiers are indicated below the human CEACAM1N domain sequence. Amino acid numbering (1) starts at the first amino acid of the leader sequence. SNPs commonly co-inherited (haplotype) are depicted as colored boxes connected by lines. #: A to V in human CEACAM1 increases the affinity to Helicobacter pylori HopQ AD-I adhesin 1.7-fold . The regions which contain critical amino acids important for pathogen adhesin binding are highlighted by blue lines . GWD, Gambian in Western Division—The Gambia, Mandinka; MSL, Mende, in Sierra Leone; YRI, Yoruba in Ibadan, Nigeria.
Kalign Multiple Protein Sequence Alignment Tool, supplied by Inserm Transfert, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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High and low frequency non-synonymous single nucleotide polymorphisms (SNPs) in human CEACAM1 N domain. ( A ) The amino acid sequences of the mature CEACAM1 N domain (leader sequences removed) from human (Hsa), bonobo (Ppa), and chimpanzee (Ptr) were aligned using the <t>KALIGN</t> multiple <t>protein</t> <t>sequence</t> alignment program. Amino acids deviating from the human sequence are underlined. The position of common SNPs found in certain African tribes are indicated by green boxes. A less common SNP at a position with variation in the other apes is marked in blue. A low frequency, functionally relevant SNP is boxed with red lines. The degree of conservation of the sequences is shown at the bottom of the graph [* = identical (red), : = conservative changes (green), . = less stringent conservative changes (blue)]. The location, sequence, and name of active human CEACAM1 peptides functionally tested in a granulocyte activation assay [ , , ] are highlighted and shown below the CEACAM1 N exon amino acid sequence alignment. ( B ) High and selected low frequency non-synonymous SNPs were derived from the 1000 Genomes Project Phase 3 and Gambian Genome Variation Project; their highest population frequency in the indicated population and corresponding identifiers are indicated below the human CEACAM1N domain sequence. Amino acid numbering (1) starts at the first amino acid of the leader sequence. SNPs commonly co-inherited (haplotype) are depicted as colored boxes connected by lines. #: A to V in human CEACAM1 increases the affinity to Helicobacter pylori HopQ AD-I adhesin 1.7-fold . The regions which contain critical amino acids important for pathogen adhesin binding are highlighted by blue lines . GWD, Gambian in Western Division—The Gambia, Mandinka; MSL, Mende, in Sierra Leone; YRI, Yoruba in Ibadan, Nigeria.
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High and low frequency non-synonymous single nucleotide polymorphisms (SNPs) in human CEACAM1 N domain. ( A ) The amino acid sequences of the mature CEACAM1 N domain (leader sequences removed) from human (Hsa), bonobo (Ppa), and chimpanzee (Ptr) were aligned using the <t>KALIGN</t> multiple <t>protein</t> <t>sequence</t> alignment program. Amino acids deviating from the human sequence are underlined. The position of common SNPs found in certain African tribes are indicated by green boxes. A less common SNP at a position with variation in the other apes is marked in blue. A low frequency, functionally relevant SNP is boxed with red lines. The degree of conservation of the sequences is shown at the bottom of the graph [* = identical (red), : = conservative changes (green), . = less stringent conservative changes (blue)]. The location, sequence, and name of active human CEACAM1 peptides functionally tested in a granulocyte activation assay [ , , ] are highlighted and shown below the CEACAM1 N exon amino acid sequence alignment. ( B ) High and selected low frequency non-synonymous SNPs were derived from the 1000 Genomes Project Phase 3 and Gambian Genome Variation Project; their highest population frequency in the indicated population and corresponding identifiers are indicated below the human CEACAM1N domain sequence. Amino acid numbering (1) starts at the first amino acid of the leader sequence. SNPs commonly co-inherited (haplotype) are depicted as colored boxes connected by lines. #: A to V in human CEACAM1 increases the affinity to Helicobacter pylori HopQ AD-I adhesin 1.7-fold . The regions which contain critical amino acids important for pathogen adhesin binding are highlighted by blue lines . GWD, Gambian in Western Division—The Gambia, Mandinka; MSL, Mende, in Sierra Leone; YRI, Yoruba in Ibadan, Nigeria.
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High and low frequency non-synonymous single nucleotide polymorphisms (SNPs) in human CEACAM1 N domain. ( A ) The amino acid sequences of the mature CEACAM1 N domain (leader sequences removed) from human (Hsa), bonobo (Ppa), and chimpanzee (Ptr) were aligned using the <t>KALIGN</t> multiple <t>protein</t> <t>sequence</t> alignment program. Amino acids deviating from the human sequence are underlined. The position of common SNPs found in certain African tribes are indicated by green boxes. A less common SNP at a position with variation in the other apes is marked in blue. A low frequency, functionally relevant SNP is boxed with red lines. The degree of conservation of the sequences is shown at the bottom of the graph [* = identical (red), : = conservative changes (green), . = less stringent conservative changes (blue)]. The location, sequence, and name of active human CEACAM1 peptides functionally tested in a granulocyte activation assay [ , , ] are highlighted and shown below the CEACAM1 N exon amino acid sequence alignment. ( B ) High and selected low frequency non-synonymous SNPs were derived from the 1000 Genomes Project Phase 3 and Gambian Genome Variation Project; their highest population frequency in the indicated population and corresponding identifiers are indicated below the human CEACAM1N domain sequence. Amino acid numbering (1) starts at the first amino acid of the leader sequence. SNPs commonly co-inherited (haplotype) are depicted as colored boxes connected by lines. #: A to V in human CEACAM1 increases the affinity to Helicobacter pylori HopQ AD-I adhesin 1.7-fold . The regions which contain critical amino acids important for pathogen adhesin binding are highlighted by blue lines . GWD, Gambian in Western Division—The Gambia, Mandinka; MSL, Mende, in Sierra Leone; YRI, Yoruba in Ibadan, Nigeria.
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High and low frequency non-synonymous single nucleotide polymorphisms (SNPs) in human CEACAM1 N domain. ( A ) The amino acid sequences of the mature CEACAM1 N domain (leader sequences removed) from human (Hsa), bonobo (Ppa), and chimpanzee (Ptr) were aligned using the <t>KALIGN</t> multiple <t>protein</t> <t>sequence</t> alignment program. Amino acids deviating from the human sequence are underlined. The position of common SNPs found in certain African tribes are indicated by green boxes. A less common SNP at a position with variation in the other apes is marked in blue. A low frequency, functionally relevant SNP is boxed with red lines. The degree of conservation of the sequences is shown at the bottom of the graph [* = identical (red), : = conservative changes (green), . = less stringent conservative changes (blue)]. The location, sequence, and name of active human CEACAM1 peptides functionally tested in a granulocyte activation assay [ , , ] are highlighted and shown below the CEACAM1 N exon amino acid sequence alignment. ( B ) High and selected low frequency non-synonymous SNPs were derived from the 1000 Genomes Project Phase 3 and Gambian Genome Variation Project; their highest population frequency in the indicated population and corresponding identifiers are indicated below the human CEACAM1N domain sequence. Amino acid numbering (1) starts at the first amino acid of the leader sequence. SNPs commonly co-inherited (haplotype) are depicted as colored boxes connected by lines. #: A to V in human CEACAM1 increases the affinity to Helicobacter pylori HopQ AD-I adhesin 1.7-fold . The regions which contain critical amino acids important for pathogen adhesin binding are highlighted by blue lines . GWD, Gambian in Western Division—The Gambia, Mandinka; MSL, Mende, in Sierra Leone; YRI, Yoruba in Ibadan, Nigeria.
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High and low frequency non-synonymous single nucleotide polymorphisms (SNPs) in human CEACAM1 N domain. ( A ) The amino acid sequences of the mature CEACAM1 N domain (leader sequences removed) from human (Hsa), bonobo (Ppa), and chimpanzee (Ptr) were aligned using the <t>KALIGN</t> multiple <t>protein</t> <t>sequence</t> alignment program. Amino acids deviating from the human sequence are underlined. The position of common SNPs found in certain African tribes are indicated by green boxes. A less common SNP at a position with variation in the other apes is marked in blue. A low frequency, functionally relevant SNP is boxed with red lines. The degree of conservation of the sequences is shown at the bottom of the graph [* = identical (red), : = conservative changes (green), . = less stringent conservative changes (blue)]. The location, sequence, and name of active human CEACAM1 peptides functionally tested in a granulocyte activation assay [ , , ] are highlighted and shown below the CEACAM1 N exon amino acid sequence alignment. ( B ) High and selected low frequency non-synonymous SNPs were derived from the 1000 Genomes Project Phase 3 and Gambian Genome Variation Project; their highest population frequency in the indicated population and corresponding identifiers are indicated below the human CEACAM1N domain sequence. Amino acid numbering (1) starts at the first amino acid of the leader sequence. SNPs commonly co-inherited (haplotype) are depicted as colored boxes connected by lines. #: A to V in human CEACAM1 increases the affinity to Helicobacter pylori HopQ AD-I adhesin 1.7-fold . The regions which contain critical amino acids important for pathogen adhesin binding are highlighted by blue lines . GWD, Gambian in Western Division—The Gambia, Mandinka; MSL, Mende, in Sierra Leone; YRI, Yoruba in Ibadan, Nigeria.
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High and low frequency non-synonymous single nucleotide polymorphisms (SNPs) in human CEACAM1 N domain. ( A ) The amino acid sequences of the mature CEACAM1 N domain (leader sequences removed) from human (Hsa), bonobo (Ppa), and chimpanzee (Ptr) were aligned using the <t>KALIGN</t> multiple <t>protein</t> <t>sequence</t> alignment program. Amino acids deviating from the human sequence are underlined. The position of common SNPs found in certain African tribes are indicated by green boxes. A less common SNP at a position with variation in the other apes is marked in blue. A low frequency, functionally relevant SNP is boxed with red lines. The degree of conservation of the sequences is shown at the bottom of the graph [* = identical (red), : = conservative changes (green), . = less stringent conservative changes (blue)]. The location, sequence, and name of active human CEACAM1 peptides functionally tested in a granulocyte activation assay [ , , ] are highlighted and shown below the CEACAM1 N exon amino acid sequence alignment. ( B ) High and selected low frequency non-synonymous SNPs were derived from the 1000 Genomes Project Phase 3 and Gambian Genome Variation Project; their highest population frequency in the indicated population and corresponding identifiers are indicated below the human CEACAM1N domain sequence. Amino acid numbering (1) starts at the first amino acid of the leader sequence. SNPs commonly co-inherited (haplotype) are depicted as colored boxes connected by lines. #: A to V in human CEACAM1 increases the affinity to Helicobacter pylori HopQ AD-I adhesin 1.7-fold . The regions which contain critical amino acids important for pathogen adhesin binding are highlighted by blue lines . GWD, Gambian in Western Division—The Gambia, Mandinka; MSL, Mende, in Sierra Leone; YRI, Yoruba in Ibadan, Nigeria.
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High and low frequency non-synonymous single nucleotide polymorphisms (SNPs) in human CEACAM1 N domain. ( A ) The amino acid sequences of the mature CEACAM1 N domain (leader sequences removed) from human (Hsa), bonobo (Ppa), and chimpanzee (Ptr) were aligned using the <t>KALIGN</t> multiple <t>protein</t> <t>sequence</t> alignment program. Amino acids deviating from the human sequence are underlined. The position of common SNPs found in certain African tribes are indicated by green boxes. A less common SNP at a position with variation in the other apes is marked in blue. A low frequency, functionally relevant SNP is boxed with red lines. The degree of conservation of the sequences is shown at the bottom of the graph [* = identical (red), : = conservative changes (green), . = less stringent conservative changes (blue)]. The location, sequence, and name of active human CEACAM1 peptides functionally tested in a granulocyte activation assay [ , , ] are highlighted and shown below the CEACAM1 N exon amino acid sequence alignment. ( B ) High and selected low frequency non-synonymous SNPs were derived from the 1000 Genomes Project Phase 3 and Gambian Genome Variation Project; their highest population frequency in the indicated population and corresponding identifiers are indicated below the human CEACAM1N domain sequence. Amino acid numbering (1) starts at the first amino acid of the leader sequence. SNPs commonly co-inherited (haplotype) are depicted as colored boxes connected by lines. #: A to V in human CEACAM1 increases the affinity to Helicobacter pylori HopQ AD-I adhesin 1.7-fold . The regions which contain critical amino acids important for pathogen adhesin binding are highlighted by blue lines . GWD, Gambian in Western Division—The Gambia, Mandinka; MSL, Mende, in Sierra Leone; YRI, Yoruba in Ibadan, Nigeria.
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High and low frequency non-synonymous single nucleotide polymorphisms (SNPs) in human CEACAM1 N domain. ( A ) The amino acid sequences of the mature CEACAM1 N domain (leader sequences removed) from human (Hsa), bonobo (Ppa), and chimpanzee (Ptr) were aligned using the <t>KALIGN</t> multiple <t>protein</t> <t>sequence</t> alignment program. Amino acids deviating from the human sequence are underlined. The position of common SNPs found in certain African tribes are indicated by green boxes. A less common SNP at a position with variation in the other apes is marked in blue. A low frequency, functionally relevant SNP is boxed with red lines. The degree of conservation of the sequences is shown at the bottom of the graph [* = identical (red), : = conservative changes (green), . = less stringent conservative changes (blue)]. The location, sequence, and name of active human CEACAM1 peptides functionally tested in a granulocyte activation assay [ , , ] are highlighted and shown below the CEACAM1 N exon amino acid sequence alignment. ( B ) High and selected low frequency non-synonymous SNPs were derived from the 1000 Genomes Project Phase 3 and Gambian Genome Variation Project; their highest population frequency in the indicated population and corresponding identifiers are indicated below the human CEACAM1N domain sequence. Amino acid numbering (1) starts at the first amino acid of the leader sequence. SNPs commonly co-inherited (haplotype) are depicted as colored boxes connected by lines. #: A to V in human CEACAM1 increases the affinity to Helicobacter pylori HopQ AD-I adhesin 1.7-fold . The regions which contain critical amino acids important for pathogen adhesin binding are highlighted by blue lines . GWD, Gambian in Western Division—The Gambia, Mandinka; MSL, Mende, in Sierra Leone; YRI, Yoruba in Ibadan, Nigeria.
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High and low frequency non-synonymous single nucleotide polymorphisms (SNPs) in human CEACAM1 N domain. ( A ) The amino acid sequences of the mature CEACAM1 N domain (leader sequences removed) from human (Hsa), bonobo (Ppa), and chimpanzee (Ptr) were aligned using the <t>KALIGN</t> multiple <t>protein</t> <t>sequence</t> alignment program. Amino acids deviating from the human sequence are underlined. The position of common SNPs found in certain African tribes are indicated by green boxes. A less common SNP at a position with variation in the other apes is marked in blue. A low frequency, functionally relevant SNP is boxed with red lines. The degree of conservation of the sequences is shown at the bottom of the graph [* = identical (red), : = conservative changes (green), . = less stringent conservative changes (blue)]. The location, sequence, and name of active human CEACAM1 peptides functionally tested in a granulocyte activation assay [ , , ] are highlighted and shown below the CEACAM1 N exon amino acid sequence alignment. ( B ) High and selected low frequency non-synonymous SNPs were derived from the 1000 Genomes Project Phase 3 and Gambian Genome Variation Project; their highest population frequency in the indicated population and corresponding identifiers are indicated below the human CEACAM1N domain sequence. Amino acid numbering (1) starts at the first amino acid of the leader sequence. SNPs commonly co-inherited (haplotype) are depicted as colored boxes connected by lines. #: A to V in human CEACAM1 increases the affinity to Helicobacter pylori HopQ AD-I adhesin 1.7-fold . The regions which contain critical amino acids important for pathogen adhesin binding are highlighted by blue lines . GWD, Gambian in Western Division—The Gambia, Mandinka; MSL, Mende, in Sierra Leone; YRI, Yoruba in Ibadan, Nigeria.
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Image Search Results


High and low frequency non-synonymous single nucleotide polymorphisms (SNPs) in human CEACAM1 N domain. ( A ) The amino acid sequences of the mature CEACAM1 N domain (leader sequences removed) from human (Hsa), bonobo (Ppa), and chimpanzee (Ptr) were aligned using the KALIGN multiple protein sequence alignment program. Amino acids deviating from the human sequence are underlined. The position of common SNPs found in certain African tribes are indicated by green boxes. A less common SNP at a position with variation in the other apes is marked in blue. A low frequency, functionally relevant SNP is boxed with red lines. The degree of conservation of the sequences is shown at the bottom of the graph [* = identical (red), : = conservative changes (green), . = less stringent conservative changes (blue)]. The location, sequence, and name of active human CEACAM1 peptides functionally tested in a granulocyte activation assay [ , , ] are highlighted and shown below the CEACAM1 N exon amino acid sequence alignment. ( B ) High and selected low frequency non-synonymous SNPs were derived from the 1000 Genomes Project Phase 3 and Gambian Genome Variation Project; their highest population frequency in the indicated population and corresponding identifiers are indicated below the human CEACAM1N domain sequence. Amino acid numbering (1) starts at the first amino acid of the leader sequence. SNPs commonly co-inherited (haplotype) are depicted as colored boxes connected by lines. #: A to V in human CEACAM1 increases the affinity to Helicobacter pylori HopQ AD-I adhesin 1.7-fold . The regions which contain critical amino acids important for pathogen adhesin binding are highlighted by blue lines . GWD, Gambian in Western Division—The Gambia, Mandinka; MSL, Mende, in Sierra Leone; YRI, Yoruba in Ibadan, Nigeria.

Journal: Biology

Article Title: Evolution of CEACAM1 N Domain Biologically Active Sites in Primates

doi: 10.3390/biology14121744

Figure Lengend Snippet: High and low frequency non-synonymous single nucleotide polymorphisms (SNPs) in human CEACAM1 N domain. ( A ) The amino acid sequences of the mature CEACAM1 N domain (leader sequences removed) from human (Hsa), bonobo (Ppa), and chimpanzee (Ptr) were aligned using the KALIGN multiple protein sequence alignment program. Amino acids deviating from the human sequence are underlined. The position of common SNPs found in certain African tribes are indicated by green boxes. A less common SNP at a position with variation in the other apes is marked in blue. A low frequency, functionally relevant SNP is boxed with red lines. The degree of conservation of the sequences is shown at the bottom of the graph [* = identical (red), : = conservative changes (green), . = less stringent conservative changes (blue)]. The location, sequence, and name of active human CEACAM1 peptides functionally tested in a granulocyte activation assay [ , , ] are highlighted and shown below the CEACAM1 N exon amino acid sequence alignment. ( B ) High and selected low frequency non-synonymous SNPs were derived from the 1000 Genomes Project Phase 3 and Gambian Genome Variation Project; their highest population frequency in the indicated population and corresponding identifiers are indicated below the human CEACAM1N domain sequence. Amino acid numbering (1) starts at the first amino acid of the leader sequence. SNPs commonly co-inherited (haplotype) are depicted as colored boxes connected by lines. #: A to V in human CEACAM1 increases the affinity to Helicobacter pylori HopQ AD-I adhesin 1.7-fold . The regions which contain critical amino acids important for pathogen adhesin binding are highlighted by blue lines . GWD, Gambian in Western Division—The Gambia, Mandinka; MSL, Mende, in Sierra Leone; YRI, Yoruba in Ibadan, Nigeria.

Article Snippet: Amino acid sequence alignments were performed using the KALIGN multiple protein sequence alignment tool ( https://npsa.lyon.inserm.fr/cgi-bin/npsa_automat.pl?page=/NPSA/npsa_kalign.html , accessed 17 April 2025).

Techniques: Sequencing, Activation Assay, Derivative Assay, Binding Assay, Western Blot